Lipid profile and non-alcoholic fatty liver disease detected by ultrasonography: is systemic inflammation a necessary mediator?
Lipid profile and non-alcoholic fatty liver disease detected by ultrasonography: is systemic inflammation a necessary mediator?
Blog Article
Aims To examine the relationship between lipid profile and non-alcoholic fatty liver (NAFL), compare the predictive strengths of different lipid indicators to NAFL, and explore the possible mechanisms.Methods Male workers from a baseline survey of a cohort of workers in southern China were included.Basic information was collected through Aronia face-to-face interviews.Plasma concentrations of fasting plasma glucose (FPG), total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were determined using a blood biochemical analyzer.
Liver sonography was used to identify NAFL cases.Regression models were used to calculate ORs, and examine the association between C-reactive protein (CRP) levels and lipid profiles.Restricted cubic spline regression with four knots was used to examine the dose-response relationship, and mediation analysis was employed to examine the mediation effect.Results h Among the 4016 male workers, 829 (20.
64%) were diagnosed with NAFL.Compared with normal lipid profile, individuals with abnormal lipid profile had higher prevalence of NAFL (OR=2.27, 95%CI: 1.85-2.
79 for TG; OR=1.45, 95%CI: 1.03-2.04 for TC; OR=1.
56, 95%CI: 1.21-2.02 for HDL; OR=1.65, 95%CI: 1.
25-2.18 for LDL; OR=2.28, 95%CI: 1.87-2.
77 for dyslipidaemia) after adjusting for potential confounders.Dose-response relationships were observed among TG, HDL, and NAFL.In addition, no significant mediation effect of C-reactive protein (CRP) was found in the association between lipid profiles and NAFL.Conclusions NEFF D94QFM1N0B N50 Built In 90cm 3 Speeds A Chimney Cooker Hood Stainless touch Abnormal TG, TC, HDL, and LDL levels were all positively associated with NAFL, while CRP has no mediating effect, and TG tended to be a better predictor of NAFL.